Composite Three‐Dimensional Woven Scaffolds with Interpenetrating Network Hydrogels to Create Functional Synthetic Articular Cartilage

作者：I‐Chien Liao, Franklin T. Moutos, Bradley T. Estes, Xuanhe Zhao, Farshid Guilak · 发表于：Advanced Functional Materials · 年份：2013 · DOI：10.1002/adfm.201300483 · 被引用次数：278 · 研究领域：Osteoarthritis Treatment and Mechanisms、Electrospun Nanofibers in Biomedical Applications、Hydrogels: synthesis, properties, applications

The development of synthetic biomaterials that possess mechanical properties that mimic those of native tissues remains an important challenge to the field of materials. In particular, articular cartilage is a complex nonlinear, viscoelastic, and anisotropic material that exhibits a very low coefficient of friction, allowing it to withstand millions of cycles of joint loading over decades of wear. Here we show that a three-dimensionally woven fiber scaffold that is infiltrated with an interpenetrating network hydrogel can provide a functional biomaterial that provides the load-bearing and tribological properties of native cartilage. An interpenetrating dual-network "tough-gel" consisting of alginate and polyacrylamide was infused into a porous three-dimensionally woven poly(ε-caprolactone) fiber scaffold, providing a versatile fiber-reinforced composite structure as a potential acellular or cell-based replacement for cartilage repair.