Reduced neuropeptide Y mRNA expression in the prefrontal cortex of subjects with bipolar disorder

作者：Laura Caberlotto, Yasmin L. Hurd · 发表于：Neuroreport · 年份：1999 · DOI：10.1097/00001756-199906030-00022 · 被引用次数：86 · 研究领域：Neuropeptides and Animal Physiology、Receptor Mechanisms and Signaling、Cardiovascular, Neuropeptides, and Oxidative Stress Research

In the present study, we compared neuropeptide Y mRNA expression levels in the prefrontal cortex (Brodmann area 9 and 46) of subjects diagnosed with major depression, bipolar disorder and schizophrenia with those in normal controls without a psychiatric history. No correlation was found regarding neuropeptide Y mRNA expression and postmortem interval, age, gender, hemisphere side, suicide as cause of death, or the history of use of substances such as alcohol, marihuana and cocaine/amphetamine. The only significant alteration found was related to the clinical diagnosis; neuropeptide Y mRNA expression was reduced in the group of bipolar subjects as compared to the controls. Overall, the present results confirm an involvement of neuropeptide Y in affective disorders, and show for the first time a specific association between NPY and bipolar disorder.