Induction of Stalk Cell Differentiation by Cyclic AMP in the Cellular Slime Mold Dictyostelium discoideum

作者：John Tyler Bonner · 发表于：Proceedings of the National Academy of Sciences · 年份：1970 · DOI：10.1073/pnas.65.1.110 · 被引用次数：208 · 研究领域：Algal biology and biofuel production、Cellular Mechanics and Interactions

Cyclic AMP, which is a cell attractant (acrasin) for Dictyostelium discoideum, will cause isolated, unaggregated cells to turn directly into stalk cells containing thick celluloselike walls and large vacuoles. From previous work we know that in the cell mass, acrasin is produced solely in the region of stalk formation during fruiting, that stalk formation involves a high level of catabolism, and that cyclic AMP stimulates catabolic enzymes in other systems. These facts obviously suggest that in the development of D. discoideum, cyclic AMP might be a key factor in stalk cell differentiation.