Fecal transplant against relapsingClostridium difficile-associated diarrhea in 32 patients

作者：Christina Jorup-Rönström, Anders Håkanson, Staffan Sandell, Ove Edvinsson, Tore Midtvedt, Anna‐Karin Persson, Elisabeth Lissa Norin · 发表于：Scandinavian Journal of Gastroenterology · 年份：2012 · DOI：10.3109/00365521.2012.672587 · 被引用次数：82 · 研究领域：Clostridium difficile and Clostridium perfringens research、Gut microbiota and health、Gastrointestinal motility and disorders

Clostridium difficile-associated disease (CDAD) with frequent watery stools, sometimes with painful bowel movements, fever and sickness, is probably the major known cause of antibiotic-associated diarrhea and colitis, most probably depending on a disruption of the normal intestinal balance in the microbiome. In this study, we have inoculated a mixture of fecal microbes--as an enema--originating from a healthy Scandinavian middle-aged donor, regularly re-cultivated under strict anaerobic conditions for more than 10 years, to 32 patients. Twenty-two patients (69%) were durably cured. In those patients receiving the transplant by colonoscopy, four out of five were cured. To the best of our knowledge, this is the first time a fecal culture of microbes has retained the possibility for years to cure a substantial number of patients with CDAD.