Magnetite‐Loaded Polymeric Micelles as Ultrasensitive Magnetic‐Resonance Probes

作者：Hua Ai, Chris A. Flask, Brent D. Weinberg, Xintao Shuai, Mark David Pagel, D. E. Farrell, Jeffrey L. Duerk, Jinhao Gao · 发表于：Advanced Materials · 年份：2005 · DOI：10.1002/adma.200401904 · 被引用次数：466 · 研究领域：Nanoparticle-Based Drug Delivery、Lanthanide and Transition Metal Complexes、Characterization and Applications of Magnetic Nanoparticles

Increased contrast in magnetic resonance imaging (MRI) is accomplished using polymeric micelles loaded with superparamagnetic iron oxide (SPIO) nanoparticles encapsulated in biocompatible, biodegradable poly(ϵ-caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) copolymers (see Figure). The loaded micelles show significantly improved T2 relaxivities and remarkable MRI detection sensitivity.