Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

作者：GEORGE V. THOMAS, Chris Tran, Ingo K. Mellinghoff, Derek S. Welsbie, Emily Chan, Barbara J. Fueger, Johannes Czernin, Charles L. Sawyers · 发表于：Nature Medicine · 年份：2005 · DOI：10.1038/nm1337 · 被引用次数：610 · 研究领域：Cancer, Hypoxia, and Metabolism、Renal cell carcinoma treatment、PI3K/AKT/mTOR signaling in cancer