Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

作者：Uno Shu, Mamoru Kiniwa, Chang You Wu, Charles R. Maliszewski, Nadia Vezzio, John Hakimi, Maurice K. Gately, Guy J. Delespesse · 发表于：European Journal of Immunology · 年份：1995 · DOI：10.1002/eji.1830250442 · 被引用次数：419 · 研究领域：Immune Cell Function and Interaction、T-cell and B-cell Immunology、Immunotherapy and Immune Responses

Previous studies on the production of interleukin-12 (IL-12) have shown that it is released, together with other proinflammatory cytokines, shortly after exposure of phagocytic cells to a variety of pathogens. We here report that IL-12 is also released during the recall response to soluble antigen (Ag) devoid of intrinsic adjuvant activity. We show that activated T cells induce the production of IL-12 by monocytes via a mechanism involving the interaction of T cell-associated CD40 ligand with CD40 on monocytes. The data suggest that Ag presentation on monocytes favors the persistence of type 1 responses.