CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTES

作者：David H. Katz, Toshiyuki Hamaoka, Martin E. Dorf, Paul H. Maurer, Baruj Benacerraf · 发表于：The Journal of Experimental Medicine · 年份：1973 · DOI：10.1084/jem.138.3.734 · 被引用次数：192 · 研究领域：T-cell and B-cell Immunology、Immune Cell Function and Interaction、Immunotherapy and Immune Responses

In the present study we have asked the question of whether F(1) carrier-primed T cells can serve as helper cells for either or both parental B cells when (a) the carrier molecule employed is under genetic control such that one parental strain is a responder and the other is a nonresponder, and (b) the determinant specificity of the parental B cells being assessed is not under genetic control and bears no relationship to the specificity of the carrier molecule. Utilizing the system of immune response gene control of responses to the terpolymer L-glutamic acid-L-lysine-L-tyrosine (GLT) to which A strain mice (H-2(a)) are nonresponders, whereas BALB/c (H-2(d)) and (BALB/c x A)F(1) hybrids (CAF(1)) are responders, these studies demonstrate that GLT-primed T cells of CAF(1) donors can provide for responder BALB/c, but not for nonresponder A/J, the required stimulus for the anti-DNP responses of DNP-specific B cells of these respective parental strains to the DNP conjugate of GLT. The implications of these findings for Ir gene function in physiologic T-B cell interactions are discussed in detail.