Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products

作者：Jo Handelsman, Michelle R. Rondon, Sean F. Brady, Jon Clardy, Robert M. Goodman · 发表于：Chemistry & Biology · 年份：1998 · DOI：10.1016/s1074-5521(98)90108-9 · 被引用次数：1993 · 研究领域：Microbial Community Ecology and Physiology、Microbial Natural Products and Biosynthesis、Genomics and Phylogenetic Studies

Cultured soil microorganisms have provided a rich source of natural-product chemistry. Because only a tiny fraction of soil microbes from soil are readily cultured, soil might be the greatest untapped resource for novel chemistry. The concept of cloning the metagenome to access the collective genomes and the biosynthetic machinery of soil microflora is explored here.