Association of glutathione S-transferase P1 gene polymorphism with the risk of small-cell carcinoma of lung cancer

作者：Chao Ou, Bo Zhu, Huiliu Zhao, Lingsha Huang, Peizhang Li, Lao Ming, Le‐Qun Li · 发表于：Journal of Receptors and Signal Transduction · 年份：2014 · DOI：10.3109/10799893.2014.942463 · 被引用次数：7 · 研究领域：Glutathione Transferases and Polymorphisms、Genomics, phytochemicals, and oxidative stress、BRCA gene mutations in cancer

The conclusions of the published reports on the relationship between glutathione S-transferase P1 (GSTP1) gene polymorphism and the risk of small-cell carcinoma of lung cancer are still debated. GSTP1 is one of the important mutant sites reported at present. This meta-analysis was performed to evaluate the association between GSTP1 and the risk of small-cell carcinoma of lung cancer. The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method. Ten reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and small-cell carcinoma of lung cancer. The G allele and GG genotype were not associated with the susceptibility of risk of small-cell carcinoma in overall populations, East-Asians and Turkish population. However, there was an association between GG genotype with the risk of small-cell carcinoma in Caucasians. In conclusion, GG genotype was associated with the risk of small-cell carcinoma in Caucasian patients with lung cancer. However, GSTP1 A/G gene polymorphism is not associated with the susceptibility of small-cell carcinoma in overall populations, East-Asians and Turkish population.