Susceptibility of Chinese rhesus monkeys to SIV infection

作者：Tricia H. Burdo, Maria Cecília Garibaldi Marcondes, Caroline M. Lanigan, M. C. T. Penedo, Howard S. Fox · 发表于：AIDS · 年份：2005 · DOI：10.1097/01.aids.0000186823.76230.33 · 被引用次数：49 · 研究领域：HIV Research and Treatment、HIV/AIDS Research and Interventions、Cytomegalovirus and herpesvirus research

The use of China-derived monkeys in AIDS research has been limited by reports of reduced susceptibility to SIV. We performed a serial passage of SIV in Chinese macaques, which resulted in a viral stock capable of inducing simian AIDS and high levels of replication in these animals. Similar to HIV in humans, SIV pathogenesis in non-human primates is not limited by geographical origin. Chinese macaques are useful in pathogenesis, vaccine, and therapeutic studies in AIDS.