A “green” strategy to construct non-covalent, stable and bioactive coatings on porous MOF nanoparticles

作者：Valentina Agostoni, Patricia Horcajada, Magali Noiray, Milo Malanga, Ahmet Aykaç, László Jicsinszky, Antonio Vargas‐Berenguel, Nicolas Sémiramoth, Samia Daoud-Mahammed, Valérie Nicolas, Charlotte Martineau, Françis Taulelle, Jackie Vigneron, Arnaud Etchéberry, Christian Serre, Ruxandra Gref · 发表于：Scientific Reports · 年份：2015 · DOI：10.1038/srep07925 · 被引用次数：180 · 研究领域：Metal-Organic Frameworks: Synthesis and Applications、Dendrimers and Hyperbranched Polymers、MXene and MAX Phase Materials

Nanoparticles made of metal-organic frameworks (nanoMOFs) attract a growing interest in gas storage, separation, catalysis, sensing and more recently, biomedicine. Achieving stable, versatile coatings on highly porous nanoMOFs without altering their ability to adsorb molecules of interest represents today a major challenge. Here we bring the proof of concept that the outer surface of porous nanoMOFs can be specifically functionalized in a rapid, biofriendly and non-covalent manner, leading to stable and versatile coatings. Cyclodextrin molecules bearing strong iron complexing groups (phosphates) were firmly anchored to the nanoMOFs' surface, within only a few minutes, simply by incubation with aqueous nanoMOF suspensions. The coating procedure did not affect the nanoMOF porosity, crystallinity, adsorption and release abilities. The stable cyclodextrin-based coating was further functionalized with: i) targeting moieties to increase the nanoMOF interaction with specific receptors and ii) poly(ethylene glycol) chains to escape the immune system. These results pave the way towards the design of surface-engineered nanoMOFs of interest for applications in the field of targeted drug delivery, catalysis, separation and sensing.