Poor description of non-pharmacological interventions: analysis of consecutive sample of randomised trials

作者：Tammy Hoffmann, C. Erueti, Paul Glasziou · 发表于：BMJ · 年份：2013 · DOI：10.1136/bmj.f3755 · 被引用次数：384 · 研究领域：Meta-analysis and systematic reviews、Health Policy Implementation Science、Pharmaceutical industry and healthcare

OBJECTIVES: To evaluate the completeness of descriptions of non-pharmacological interventions in randomised trials, identify which elements are most frequently missing, and assess whether authors can provide missing details. DESIGN: Analysis of consecutive sample of randomised trials of non-pharmacological interventions. DATA SOURCES AND STUDY SELECTION: All reports of randomised trials of non-pharmacological interventions published in 2009 in six leading general medical journals; 133 trial reports, with 137 interventions, met the inclusion criteria. DATA COLLECTION: Using an eight item checklist, two raters assessed the primary full trial report, plus any reference materials, appendices, or websites. Questions about missing details were emailed to corresponding authors, and relevant items were then reassessed. RESULTS: Of 137 interventions, only 53 (39%) were adequately described; this was increased to 81 (59%) by using 63 responses from 88 contacted authors. The most frequently missing item was the "intervention materials" (47% complete), but it also improved the most after author response (92% complete). Whereas some authors (27/70) provided materials or further information, other authors (21/70) could not; their reasons included copyright or intellectual property concerns, not having the materials or intervention details, or being unaware of their importance. Although 46 (34%) trial interventions had further information or materials readily available on a website, many we...