Experimental ulcerative disease of the colon in animals.

作者：James Watt, Raphael Marcus · 发表于：Gut · 年份：1973 · DOI：10.1136/gut.14.6.506 · 被引用次数：96 · 研究领域：Animal Nutrition and Physiology、Effects of Environmental Stressors on Livestock、Viral gastroenteritis research and epidemiology

Progress report Experimental ulcerative disease of the colon in animalsUntil recent years, there have been few successful attempts to produce experimental ulcerative disease of the colon.Several methods, including the injection of cholinergic and adrenergic drugs, the prolonged administration of histamine and histamine-releasers, the local injection of collagenase, the oral or intraarterial administration of lysozyme, as well as immunological procedures, have been used to produce experimental 'colitis' in various animal species, but the significance of these reactions in relation to the clinical condition in man remains in doubt'.Of considerable interest from the immunological aspect is the work of Zweibaum, Morard, and Halpern2.They immunized rats with living E. coli injected subcutaneously in Freund's adjuvant and produced a form of haemorrhagic ulcerative 'colitis', which they considered as being very similar to human ulcerative colitis in its symptoms, course, and histological characteristics.Four years ago, it was reported that extracts of various red seaweeds fed to animals in their drinking water caused ulcerative disease of the colon in several species, including guinea-pigs, rabbits, rats, amd mice3.The extracts contained carrageenan, a sulphated polysaccharide of high molecular weight (100000-800000)4.Mild acid hydrolysis of the native carrageenan produced a degraded product with a molecular weight of less than 30000 but retaining its original sulphate content and p...