Action of Bleomycin on DNA and RNA

作者：Wernér E.G. Müller, Zen-Ichi Yamazaki, Hans-Joachim Breter, Rudolf Karl Zahn · 发表于：European Journal of Biochemistry · 年份：1972 · DOI：10.1111/j.1432-1033.1972.tb02560.x · 被引用次数：194 · 研究领域：Metal complexes synthesis and properties、DNA and Nucleic Acid Chemistry、Synthesis and Biological Evaluation

Bleomycin, exclusively yet not necessarily, affects thymidine‐containing compounds such as DNA and polydeoxyribonucleotides by releasing free thymine and leaving aldehyde functions. Bleomycin action can be enhanced by adding reducing as well as oxidizing agents. Several radical scavangers were without influence. The guanidino moiety in the bleomycin could be traced as a functionally essential group. Molecular morphology and base sequence of the DNA strongly influence bleomycin activity. High bleomycin concentrations, besides modifying DNA into oligothyminic or athyminic nucleic acids, cause strand scissions. Possible reaction mechanisms are discussed.