Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics

作者：Keith R. Hornberger, Xin Chen, Andrew P. Crew, Andrew Kleinberg, Lifu Ma, Mark J. Mulvihill, Jing Wang, Victoria L. Wilde, Mark R. Albertella, Mark Bittner, Andrew Cooke, Salam Kadhim, Jennifer Kahler, Paul Maresca, Earl W. May, Peter Meyn, Darlene Romashko, Brianna Tokar, Roy Turton · 发表于：Bioorganic & Medicinal Chemistry Letters · 年份：2013 · DOI：10.1016/j.bmcl.2013.06.054 · 被引用次数：26 · 研究领域：Protein Kinase Regulation and GTPase Signaling、Melanoma and MAPK Pathways、Signaling Pathways in Disease