The rs1014290 Polymorphism of the SLC2A9 Gene Is Associated with Type 2 Diabetes Mellitus in Han Chinese

作者：Wan‐Chun Liu, Chi‐Chih Hung, Szu‐Chia Chen, Ming‐Yen Lin, Ling-I Chen, Daw‐Yang Hwang, Jer‐Ming Chang, Jer‐Chia Tsai, Hung‐Chun Chen, Shang-Jyh Hwang · 发表于：Experimental Diabetes Research · 年份：2011 · DOI：10.1155/2011/527520 · 被引用次数：29 · 研究领域：Gout, Hyperuricemia, Uric Acid、Diabetes, Cardiovascular Risks, and Lipoproteins、Genetic Associations and Epidemiology

AIMS: The SLC2A9 gene encodes the glucose transporter 9, with the abilities of transporting both glucose and uric acid and is involved in the pancreatic glucose-stimulated insulin secretion. The single nucleotide polymorphisms (SNPs) of SLC2A9 accounted for 5% variance of serum uric acid (UA). UA was identified as a risk factor for type 2 diabetes mellitus (DM). We investigated whether the SLC2A9 gene variations are associated with type 2 DM in Han Chinese. METHODS: Three common SNPs of the SLC2A9, rs1014290, rs2280205, and rs3733591, were genotyped in 1003 Han Chinese randomly selected from Kaohsiung, Taiwan. RESULTS: The variant SNP rs1014290 is associated with decreased 0.12-fold risk of type 2 DM (P = .002). Per-copy increase in the minor C-allele results in 0.13 mmol/L (P = .037) and 10.03 μmol/L (P = .016) decrease in serum glucose and UA, respectively. CONCLUSIONS: The SNP rs1014290 within the SLC2A9 gene is associated with type 2 DM in Han Chinese.