The Suprachiasmatic Nucleus Generates the Diurnal Changes in Plasma Leptin Levels

作者：Andries Kalsbeek, Eric Fliers, Johannes Anthonius Romijn, Susanne Eva la Fleur, Joke Wortel, Onno Bakker, Erik Endert, Ruud M. Buijs · 发表于：Endocrinology · 年份：2001 · DOI：10.1210/endo.142.6.8197 · 被引用次数：300 · 研究领域：Regulation of Appetite and Obesity、Biochemical Analysis and Sensing Techniques、Circadian rhythm and melatonin

At present it is not clear which factors are responsible for the diurnal pattern of plasma leptin levels, although the timing of food intake and circulating hormones such as glucocorticoids and insulin have both been proposed as independent determinants. In this study we show that ablation of the biological clock by thermal lesions of the hypothalamic suprachiasmatic nucleus (SCN) completely eliminates the diurnal pattern of plasma leptin levels. By contrast, removal of the diurnal corticosterone signal by adrenalectomy and corticosterone replacement did not affect diurnal plasma leptin levels. More importantly, removal of the nocturnal feeding signal by submitting the animals to a regular feeding schedule of six meals per day did not abolish the diurnal plasma leptin levels. However, both SCN lesions and the regular feeding schedule did cause an increase in the 24-h mean plasma leptin levels. As neither rhythmic feeding, insulin, or corticosterone signals can completely explain the diurnal plasma leptin rhythm, we conclude that biological clock control of the sympathetic input to the adipocyte is essential for regulation of the daily rhythm in leptin release.