Relationship of Cardiovascular Risk Factors to Echocardiographic Left Ventricular Mass in Healthy Young Black and White Adult Men and Women

作者：Julius M. Gardin, Lynne E. Wagenknecht, Hoda Anton‐Culver, John M. Flack, Samuel S. Gidding, Tom Kurosaki, Nathan D. Wong, Teri A. Manolio · 发表于：Circulation · 年份：1995 · DOI：10.1161/01.cir.92.3.380 · 被引用次数：305 · 研究领域：Cardiovascular Function and Risk Factors、Blood Pressure and Hypertension Studies、Cardiovascular Health and Disease Prevention

BACKGROUND: The objective of this study was to describe the distribution of echo left ventricular (LV) mass and its association with demographic and cardiovascular risk factors in a large race- and sex-balanced cohort of young adults. Recent epidemiological data have suggested that M-mode echocardiographically determined LV hypertrophy is an independent predictor of mortality and morbidity from coronary heart disease (CHD) in older adults. Echocardiographic LV mass has been associated in middle-aged and older adults with multiple factors including age, arterial blood pressure, body mass, and sex. However, there are few data describing the distribution of echo LV mass among black and white young adult men and women and relating LV mass to cardiovascular disease risk factors within race-sex subgroups. METHODS AND RESULTS: CARDIA (Coronary Artery Risk Development in Young Adults) is a multicenter study of young adults, including approximately equal proportions of black and white men and women aged 23 to 35 years at the time of echo examination (1990 through 1991). Two-dimensionally guided M-mode echocardiograms were attempted in 4243 participants with recordings deemed acceptable for calculation of LV mass, that is, of at least fair quality score, obtained in 3840 (90.5% of the 1990-1991 cohort). M-mode LV mass was calculated from the formula of Devereux and Reicheck, adapted for use with measurements made according to the American Society of Echocardiography Standards. LV mass ...