Copper and Oxidative Stress in the Pathogenesis of Alzheimer’s Disease

作者：Gözde Eskici, Paul H. Axelsen · 发表于：Biochemistry · 年份：2012 · DOI：10.1021/bi3006169 · 被引用次数：291 · 研究领域：Alzheimer's disease research and treatments、Trace Elements in Health、Heavy Metal Exposure and Toxicity

Copper is a redox-active metal with many important biological roles. Consequently, its distribution and oxidation state are subject to stringent regulation. A large body of clinicopathological, circumstantial, and epidemiological evidence suggests that the dysregulation of copper is intimately involved in the pathogenesis of Alzheimer's disease. Other light transition metals such as iron and zinc may affect copper regulation by competing for copper binding sites and transporters. Therapeutic interventions targeting the regulation of copper are promising, but large gaps in our understanding of copper biochemistry, amyloidogenesis, and the nature of oxidative stress in the brain must be addressed.