Ketamine as a Novel Antidepressant: From Synapse to Behavior

作者：James W. Murrough · 发表于：Clinical Pharmacology & Therapeutics · 年份：2011 · DOI：10.1038/clpt.2011.244 · 被引用次数：172 · 研究领域：Treatment of Major Depression、Tryptophan and brain disorders、Neuroscience and Neuropharmacology Research

Recent reports of a rapid antidepressant effect of the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, even in treatment-resistant populations, have spurred translational therapeutic and neuroscience research aimed at elucidating ketamine's mechanism of action. This article provides a concise overview of research findings that pertain to the effects of low-dose ketamine at the cellular, neurocircuitry, and behavioral levels and describes an integrated model of the action of ketamine in the treatment of depression.