Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II

作者：Michael E. Dahmus · 发表于：Journal of Biological Chemistry · 年份：1996 · DOI：10.1074/jbc.271.32.19009 · 被引用次数：500 · 研究领域：RNA and protein synthesis mechanisms、RNA Research and Splicing、RNA modifications and cancer

RNA polymerase (RNAP)1 II is responsible for the synthesis of pre-mRNA in eukaryotic cells. The subunit structure of RNAP II is similar to that of other RNAPs in that it is comprised of two large subunits with a molecular weight in excess of 100,000 and a collection of smaller subunits (1, 2). However, the largest subunit of RNAP II is unique in that it contains an unusual domain at its C terminus comprised of tandem repeats of the consensus sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser (3). The consensus repeat has been conserved in evolution although the number of repeats present varies in different species.