Dopamine Receptor Binding Enhancement Accompanies Lesion-Induced Behavioral Supersensitivity

作者：Ian Creese, David R. Burt, Solomon H. Snyder · 发表于：Science · 年份：1977 · DOI：10.1126/science.877576 · 被引用次数：717 · 研究领域：Neurotransmitter Receptor Influence on Behavior、Neuroscience and Neuropharmacology Research、Receptor Mechanisms and Signaling

The binding of [3H]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which are behaviorally supersensitive, as reflected by apomorphine-induced contralateral rotations. The enhanced binding is associated with an increased number of receptor sites with no change in their affinity.