Chest Radiography and High Resolution Computed Tomography of the Lungs in Asthma

作者：Fabrice Paganin, V. Trussard, Eric Senéterre, Pascal Chanez, Jacques Giron, Philippe Godard, Jean Paul Senac, Frédéric Michel, Jean Bousquet · 发表于：American Review of Respiratory Disease · 年份：1992 · DOI：10.1164/ajrccm/146.4.1084 · 被引用次数：182 · 研究领域：Asthma and respiratory diseases、Respiratory and Cough-Related Research、Inhalation and Respiratory Drug Delivery

CT scans have been studied only in asthmatics who were smokers, and no such study has been performed in patients with chronic uncomplicated asthma where a permanent bronchial destruction is likely to occur after a long course of the disease. The object of the study was to characterize CT-scan abnormalities and determine whether bronchial destructive lesions may be observed. Fifty-seven adults with chronic asthma of variable severity and etiology and 10 normal subjects were studied. None of the subjects smoked. Chest radiographs and HR-CT scans were performed in all patients. To discriminate between reversible and irreversible CT-scan abnormalities, two examinations were made in 10 patients with acute asthma both before and 2 wk after parenteral high dose corticosteroid treatment. The chest radiographs showed the expected abnormalities of asthma in 37.8% of the asthmatics. CT scans were abnormal in 71.9% of the asthmatics. Reversible abnormalities included mucoid impactions, acinar pattern, and lobar collapse. Irreversible abnormalities included bronchiectasis, bronchial wall-thickening, sequellar line shadows, and emphysema. Most of these abnormalities are likely to be related to bronchial destruction.