Association and linkage between alcoholism and eleven serological markers.

作者：Shirley Y. Hill, Donald W. Goodwin, Remi J. Cadoret, C. Kirk Osterland, S M Doner · 发表于：Journal of Studies on Alcohol · 年份：1975 · DOI：10.15288/jsa.1975.36.981 · 被引用次数：62 · 研究领域：Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities、Blood groups and transfusion、Sexual Differentiation and Disorders

Sera from alcoholics and their nonalcoholic first-degree relatives were analyzed for 11 serological markers. A lower prevalence of the S antigen in the nonalcoholic relatives and linkage in repulsion between the D gene of the Rh system and alcoholism were found. All the alcoholics and the relatives had an SS phenotype, when analyzed for complement C3, compared with a prevalence rate of about 50% in other studies. The first two associations involve blood groups, the latter a serum protein.