The trans Golgi Network: Sorting at the Exit Site of the Golgi Complex

作者：Gareth Wyn Griffiths, Kai Simons · 发表于：Science · 年份：1986 · DOI：10.1126/science.2945253 · 被引用次数：1188 · 研究领域：Cellular transport and secretion、Pancreatic function and diabetes、Calcium signaling and nucleotide metabolism

The Golgi complex is a series of membrane compartments through which proteins destined for the plasma membrane, secretory vesicles, and lysosomes move sequentially. A model is proposed whereby these three different classes of proteins are sorted into different vesicles in the last Golgi compartment, the trans Golgi network. This compartment corresponds to a tubular reticulum on the trans side of the Golgi stack, previously called Golgi endoplasmic reticulum lysosomes (GERL).