A good practice guide to the administration of substances and removal of blood, including routes and volumes

作者：Karl‐Heinz Diehl, Robin Hull, David B. Morton, Rudolf Pfister, Yvon Rabemampianina, David W. Smith, Jean‐Marc Vidal, Cor Van De Vorstenbosch · 发表于：Journal of Applied Toxicology · 年份：2001 · DOI：10.1002/jat.727 · 被引用次数：1568 · 研究领域：Animal testing and alternatives、Veterinary Pharmacology and Anesthesia、Effects and risks of endocrine disrupting chemicals

This article is the result of an initiative between the European Federation of Pharmaceutical Industries Associations (EFPIA) and the European Centre for the Validation of Alternative Methods (ECVAM). Its objectives are to provide the researcher in the safety evaluation laboratory with an up-to-date, easy-to-use set of data sheets to aid in the study design process whilst at the same time affording maximum welfare considerations to the experimental animals. Although this article is targeted at researchers in the European Pharmaceutical Industry, it is considered that the principles underpinning the data sets and refinement proposals are equally applicable to all those who use these techniques on animals in their research, whether in research institutes, universities or other sectors of industry. The implications of this article may lead to discussion with regulators, such as those responsible for pharmacopoeial testing. There are numerous publications dealing with the administration of test substances and the removal of blood samples, and many laboratories also have their own "in-house" guidelines that have been developed by custom and practice over many years. Within European Union Directive 86/609EEC1 we have an obligation to refine experiments to cause the minimum amount of stress. We hope that this article will provide background data useful to those responsible for protocol design and review. This guide is based on peer-reviewed publications whenever possible, but where ...