Colonic release of 5‐amino salicylic acid from an oral preparation in active ulcerative colitis.

作者：M. J. Dew, Robert E. J. Ryder, Nathaniel Rutherford Evans, B K Evans, J. Rhodes · 发表于：British Journal of Clinical Pharmacology · 年份：1983 · DOI：10.1111/j.1365-2125.1983.tb04983.x · 被引用次数：113 · 研究领域：Microscopic Colitis、Inflammatory Bowel Disease、Clinical Nutrition and Gastroenterology

5-amino salicylic acid coated with acrylic based resin was given orally to eight patients with active ulcerative colitis. Abdominal X-rays confirmed that the preparation released its contents in the terminal ileum and proximal colon. Differences between individuals were marked; the plasma 'concentration-time profile' reflected variations in the time taken for tablets to reach the terminal ileum.