Diabetic Cardiomyopathy Revisited

作者：Sihem Boudina, E. Dale Abel · 发表于：Circulation · 年份：2007 · DOI：10.1161/circulationaha.106.679597 · 被引用次数：1552 · 研究领域：Cardiovascular Function and Risk Factors、Metabolism, Diabetes, and Cancer、Cardiomyopathy and Myosin Studies

Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes.