Formulation and characterization of mucoadhesive buccal films of glipizide

作者：Mona Semalty, Ajay Semalty, Ganesh Kumar V · 发表于：Indian Journal of Pharmaceutical Sciences · 年份：2008 · DOI：10.4103/0250-474x.40330 · 被引用次数：193 · 研究领域：Advanced Drug Delivery Systems、Drug Solubulity and Delivery Systems、Proteoglycans and glycosaminoglycans research

Mucoadhesive buccal films of glipizide were prepared by solvent casting technique using hydroxypropylmethylcellulose, sodium carboxymethylcellulose, carbopol-934P and Eudragit RL-100. Prepared films were evaluated for weight, thickness, surface pH, swelling index, in vitro residence time, folding endurance, in vitro release, permeation studies and drug content uniformity. The films exhibited controlled release over more than 6 h. From the study it was concluded that the films containing 5 mg glipizide in 4.9% w/v hydroxypropylmethylcellulose and 1.5% w/v sodium carboxymethylcellulose exhibited satisfactory swelling, an optimum residence time and promising drug release. The formulation was found to be suitable candidate for the development of buccal films for therapeutic use.