In vivo target-specific delivery of macromolecular agents with MR-guided focused ultrasound.

作者：Mark D. Bednarski, Joon Woo Lee, Matthew R. Callstrom, King C. Li · 发表于：Radiology · 年份：1997 · DOI：10.1148/radiology.204.1.9205257 · 被引用次数：88 · 研究领域：Ultrasound and Hyperthermia Applications、Nanoparticle-Based Drug Delivery、Healthcare and Venom Research

Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed-focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.