Systemic Therapy for Colorectal Cancer

作者：Jeffrey A. Meyerhardt, Robert J. Mayer · 发表于：New England Journal of Medicine · 年份：2005 · DOI：10.1056/nejmra040958 · 被引用次数：1052 · 研究领域：Colorectal Cancer Treatments and Studies、Colorectal Cancer Surgical Treatments、Cancer Treatment and Pharmacology

Colorectal cancer is one of the most commonly diagnosed malignant diseases, with an estimated 1,023,000 new cases and 529,000 deaths worldwide each year. This review considers recently developed cytotoxic chemotherapies and biologic agents that are effective against colorectal cancer and assesses their use as treatments for metastatic disease and as components of adjuvant therapy.