Cell transplantation for stroke

作者：Sean Isaac Savitz, Daniel M. Rosenbaum, Jonathan Dinsmore, Lawrence R. Wechsler, Louis R. Caplan · 发表于：Annals of Neurology · 年份：2002 · DOI：10.1002/ana.60000 · 被引用次数：132 · 研究领域：Mesenchymal stem cell research、Electrospun Nanofibers in Biomedical Applications、Neurogenesis and neuroplasticity mechanisms

Cell transplantation has emerged as an experimental approach to restore brain function after stroke. Various cell types including porcine fetal cells, stem cells, immortalized cell lines, and marrow stromal cells are under investigation in experimental and clinical stroke trials. This review discusses the unique advantages and limitations of the different graft sources and emphasizes the current, limited knowledge about their biology. The survival, integration, and efficacy of neural transplants in stroke patients will depend on the type, severity, chronicity, adequacy of circulation, and location of the stroke lesion.