The Preferred Conformation of Oligosaccharides Derived from the Complex‐Type Carbohydrate Portions of Glycoproteins

作者：Klaus Bock, Jan Arnarp, Jörgen Lōnngren · 发表于：European Journal of Biochemistry · 年份：1982 · DOI：10.1111/j.1432-1033.1982.tb07036.x · 被引用次数：92 · 研究领域：Glycosylation and Glycoproteins Research、Carbohydrate Chemistry and Synthesis、Enzyme Structure and Function

The preferred conformation in aqueous solution of oligosaccharides related to the complex‐type carbohydrate portion of glycoproteins has been inferred from high‐resolution nuclear magnetic resonance data (both 1H and 13C) combined with hard‐sphere exo‐anomeric calculations. The results indicate that the N‐acetyl‐lactosamine units are arranged in such a way that they are widely separated in space. Thus, these carbohydrates can cover large surface areas of the attached protein and provide good targets for recognition by other proteins.