Twenty-Eight-Day Inhalation Toxicity Study of Silver Nanoparticles in Sprague-Dawley Rats

作者：Jun Ho Ji, Jae Hee Jung, Sang Soo Kim, Jin-Uk Yoon, Jung Duck Park, Byung‐Sun Choi, Yong Hyun Chung, Il Hoon Kwon, Jayoung Jeong, Beom Seok Han, Jae Hyeg Shin, Jae Hyuck Sung, Kyung Seuk Song, Il Je Yu · 发表于：Inhalation Toxicology · 年份：2007 · DOI：10.1080/08958370701432108 · 被引用次数：449 · 研究领域：Nanoparticles: synthesis and applications、Air Quality and Health Impacts、Healthcare and Environmental Waste Management

The antibacterial effect of silver nanoparticles has resulted in their extensive application in health, electronic, and home products. Thus, the exposed population continues to increase as the applications expand. Although previous studies on silver dust, fumes, and silver compounds have revealed some insights, little is yet known about the toxicity of nano-sized silver particles, where the size and surface area are recognized as important determinants for toxicity. Thus, the inhalation toxicity of silver nanoparticles is of particular concern to ensure the health of workers and consumers. However, the dispersion of inhalable ambient nano-sized particles has been an obstacle in evaluating the effect of the inhalation of nano-sized particles on the respiratory system. Accordingly, the present study used a device that generates silver nanoparticles by evaporation/condensation using a small ceramic heater. As such, the generator was able to distribute the desired concentrations of silver nanoparticles to chambers containing experimental animals. The concentrations and distribution of the nanoparticles with respect to size were also measured directly using a differential mobility analyzer and ultrafine condensation particle counter. Therefore, the inhalation toxicity of silver nanoparticles was tested over a period of 28 days. Eight-week-old rats, weighing about 283 g for the males and 192 g for the females, were divided into 4 groups (10 rats in each group): a fresh-air control,...