Endoplasmic Reticulum Stress in Immunity

作者：Sarah E. Bettigole, Laurie H. Glimcher · 发表于：Annual Review of Immunology · 年份：2014 · DOI：10.1146/annurev-immunol-032414-112116 · 被引用次数：539 · 研究领域：Endoplasmic Reticulum Stress and Disease、Autophagy in Disease and Therapy、Pancreatic function and diabetes

Immune responses occur in the midst of a variety of cellular stresses that can severely perturb endoplasmic reticulum (ER) function. The unfolded protein response is a three-pronged signaling axis dedicated to preserving ER homeostasis. In this review, we highlight many important and emerging functional roles for ER stress in immunity, focusing on how the bidirectional cross talk between immunological processes and basic cell biology leads to pleiotropic signaling outcomes and enhanced sensitivity to inflammatory stimuli. We also discuss how dysregulated ER stress responses can provoke many diseases, including autoimmunity, firmly positioning the unfolded protein response as a major therapeutic target in human disease.