A note suggesting that the cross-bridge attachment during muscle contraction may take place in two stages

作者：Andrew Fielding Huxley · 发表于：Proceedings of the Royal Society B Biological Sciences · 年份：1973 · DOI：10.1098/rspb.1973.0006 · 被引用次数：90 · 研究领域：Cardiomyopathy and Myosin Studies、Muscle activation and electromyography studies、Cardiovascular Effects of Exercise

Abstract It has been widely assumed that the rate-limiting step in actomyosin ATPase activity during contraction is a single-stage attachment of the myosin head to a site on the thin filament. This assumption leads to a rate of energy liberation that increases monotonically with speed of shortening, in agreement with pre-war estimates of the output of work and heat; it does not explain the fall in energy release at high speeds that has been found more recently. This fall can be explained by assuming that the attachment is a two-stage process.