Antibodies to Bradykinin and Angiotensin: A Use of Carbodiimides in Immunology

作者：Theodore L. Goodfriend, Lawrence Levine, Gerald D. Fasman · 发表于：Science · 年份：1964 · DOI：10.1126/science.144.3624.1344 · 被引用次数：810 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Radiopharmaceutical Chemistry and Applications、Coagulation, Bradykinin, Polyphosphates, and Angioedema

Antibodies to bradykinin and angiotensin have been produced in rabbits by the use of conjugates containing albumin and the hapten, covalently bound. The use of water-soluble carbodiimide reagents provided an easy and rapid method of synthesis of the antigenic conjugates.