Cyclosporin‐phenytoin interaction: re‐evaluation using metabolite data.

作者：Malcolm Rowland, SK Gupta · 发表于：British Journal of Clinical Pharmacology · 年份：1987 · DOI：10.1111/j.1365-2125.1987.tb03177.x · 被引用次数：47 · 研究领域：Pharmacological Effects and Toxicity Studies、Metabolism and Genetic Disorders、Drug Transport and Resistance Mechanisms

1 Freeman et al. (1984) evoked enzyme induction to explain the lower plasma concentration of cyclosporin following phenytoin co-administration in man. 2 We have examined the whole blood concentration data of two metabolites of cyclosporin, as well as unchanged drug, all measured by h.p.l.c., associated with the above mentioned study. 3 Phenytoin produced no significant effect on either the terminal half-life of both metabolites or the ratio of area under the concentration-time curve of metabolite to parent drug. 4 These data strongly suggest that phenytoin reduces the absorption of cyclosporin; they do not generally support the idea that phenytoin induces cyclosporin metabolism.