Synthesis and antibacterial activity of novel N -acylsulfonamides

作者：Malika Berredjem, Fouzia Bouchareb, Samira Ait Kaki, Maazouz Dekhil, Nour‐Eddine Aouf · 发表于：Arabian Journal of Chemistry · 年份：2013 · DOI：10.1016/j.arabjc.2013.01.016 · 被引用次数：28 · 研究领域：Sulfur-Based Synthesis Techniques、Phenothiazines and Benzothiazines Synthesis and Activities、Organic and Inorganic Chemical Reactions

A series of novel N-acylsulfonamide derivatives were synthesized and characterized by 1H NMR, 13C NMR and HRMS. The N-acylsulfonamides were prepared in four steps (carbamoylation, sulfamoylation, deprotection and acylation) starting from chlorosulfonyl isocyanate. These compounds were evaluated in vitro as antimicrobial agents against representative strains of Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Acinetobacter, Klebsiella pneumonia and Pseudomonas aeruginosa).