Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer

作者：Yu Cheng, Anna Cristina S. Samia, Joseph Meyers, Irene. Panagopoulos, Baowei Fei, Clemens Burda · 发表于：Journal of the American Chemical Society · 年份：2008 · DOI：10.1021/ja801631c · 被引用次数：725 · 研究领域：Nanoplatforms for cancer theranostics、Nanoparticle-Based Drug Delivery、Photodynamic Therapy Research Studies

A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.