The Association of Goitrous Autoimmune Thyroiditis with HLA‐DR5*

作者：Nadir R. Farid, Laura Sampson, Hilda Moens, John M. Barnard · 发表于：Tissue Antigens · 年份：1981 · DOI：10.1111/j.1399-0039.1981.tb00700.x · 被引用次数：134 · 研究领域：T-cell and B-cell Immunology、Thyroid Disorders and Treatments、Diabetes and associated disorders

We found HLA-DR5 to be present among 53% of 40 patients with goitrous autoimmune (Hashimoto's ) thyroiditis compared to 26% of 80 controls. No deviations from those expected in the incidences of HLA-A, B, C antigens were seen. In contrast HLA-DR3 was increased among 50 patients with atrophic thyroiditis (65%) compared to controls (24%). These findings stress the immunogenetic heterogeneity between the goitrous and atrophic varieties of thyroiditis.