The vicious circle between oxidative stress and inflammation in atherosclerosis

作者：Maarten Hulsmans, Paul Holvoet · 发表于：Journal of Cellular and Molecular Medicine · 年份：2009 · DOI：10.1111/j.1582-4934.2009.00978.x · 被引用次数：270 · 研究领域：Adipokines, Inflammation, and Metabolic Diseases、Atherosclerosis and Cardiovascular Diseases、Biomarkers in Disease Mechanisms

• Introduction • Overview of molecular mechanisms explaining the association of inflammation and oxidative stress in the vessel wall • Regulatory mechanisms of interactions between oxidative stress and inflammation • Overview of molecular mechanisms explaining the association of inflammation and oxidative stress in adipose tissues • Conclusions The initial event in atherogenesis is the increased transcytosis of low density lipoprotein, and its subsequent deposition, retention and modification in the subendothelium. It is followed by the infiltration of activated inflammatory cells from the coronary circulation into the arterial wall. There they secrete reactive oxygen species (ROS) and produce oxidized lipoproteins capable of inducing endothelial cell apoptosis, and thereby plaque erosion. Activated T lymphocytes, macrophages and mast cells, accumulate in the eroded plaque where they secrete a variety of proteases capable of inducing degradation of extracellular proteins, thereby rendering the plaques more prone to rupture. This review summarizes the recent advancements in the understanding of the roles of ROS and oxidized lipoproteins in the activation of inflammatory cells and inducing signalling pathways related to cell death and apoptosis. In addition, it presents evidence that this vicious circle between oxidative stress and inflammation does not only occur in the diseased arterial wall, but also in adipose tissues. There, oxidative stress and inflammation impair adipocy...