Trauma-Induced Protein in Rat Tissues: A Physiological Role for a "Heat Shock" Protein?

作者：R. William Currie, Fredric P. White · 发表于：Science · 年份：1981 · DOI：10.1126/science.7280681 · 被引用次数：235 · 研究领域：Heat shock proteins research、Enzyme Structure and Function、Protein Structure and Dynamics

Hyperthermic shock induces the synthesis of a novel protein (P71) in many rat tissues in vivo. In incubated rat tissue slices P71 is the major protein synthesized even though it is undetectable in the tissues of a normal, unstressed rat. P71 is "heat shock" protein, and it may be induced in vivo by stimuli other than hyperthermia. These results indicate that caution must be used in studies of protein synthesis in tissue explants, since the pattern of proteins synthesized by rat tissue slices is characteristic of stressed tissue.