Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.

作者：Warner C. Greene, Richard J. Robb, Penny B. Svetlik, Cynthia M. Rusk, J M Depper, Warren J. Leonard · 发表于：The Journal of Experimental Medicine · 年份：1985 · DOI：10.1084/jem.162.1.363 · 被引用次数：119 · 研究领域：T-cell and Retrovirus Studies、Immune Cell Function and Interaction、Animal Disease Management and Epidemiology

Human interleukin 2 (IL-2) receptor cDNA derived from HUT 102B2 cells was stably expressed in murine L cells. These L cell transfectants (a) displayed surface receptors of the aberrant size of the IL-2 receptors on HUT 102B2 cells, (b) did not respond to exogenous IL-2 with augmented proliferation, and (c) expressed low affinity but not high affinity receptors for IL-2.