Tight Junction Proteins in the Skin

作者：J. M. Brandner, Sabine Kief, Ewa Wladykowski, Pavel Houdek, Ingrid Moll · 发表于：Skin Pharmacology and Physiology · 年份：2006 · DOI：10.1159/000091973 · 被引用次数：93 · 研究领域：Barrier Structure and Function Studies、Connexins and lens biology、Advanced Glycation End Products research

It has long been accepted that tight junctions (TJ) are crucial for the formation and maintenance of the paracellular barrier and for cell polarity in simple epithelia and endothelia. Moreover, it is long known that they play a role in barrier function of amphibian skin. However, only in recent years were TJ and TJ proteins identified in the epidermis of men and mice. Their involvement in the barrier function of mammalian skin has been shown. This review summarizes our current knowledge about TJ and TJ proteins in mammalian skin.