Alcohol, Amines, and Alkaloids: A Possible Biochemical Basis for Alcohol Addiction

作者：Virginia E. Davis, Michael J. Walsh · 发表于：Science · 年份：1970 · DOI：10.1126/science.167.3920.1005 · 被引用次数：562 · 研究领域：Chemical synthesis and alkaloids、Pharmacological Receptor Mechanisms and Effects、Cancer Treatment and Pharmacology

Tetrahydropapaveroline is a benzyltetrahydroisoquinoline alkaloidderivative of the biogenic amine, dopnmine. Alcohol, by way of its primary metabolite, acetaldehyde, competitively inhibits nicotinamide-adenine Sinucleotide-linked aldehyde dehydrogenase and augments the formation of tetrahydropapaveroline in vitro. The limited capacity of brain to oxidize aldehydes may be of pharmacological importance because it facilitates the production of tetrahydropapaveroline in the presence of drugs which inhibit this enzyme.