Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity

作者：Di-Fan Zhu, Guo‐Lei Zhu, Lingmei Kong, Ni-Man Bao, Lin Zhou, Yin Nian, Ming‐Hua Qiu · 发表于：Natural Products and Bioprospecting · 年份：2015 · DOI：10.1007/s13659-015-0053-7 · 被引用次数：16 · 研究领域：Estrogen and related hormone effects、Phytoestrogen effects and research、Wnt/β-catenin signaling in development and cancer

Four new 9,19-cycloartane triterpenoids, cimilactone E ( 1 ), cimilactone F ( 2 ), 2′- O -( E )-butenoyl-23- epi -26-deoxyactein ( 3 ), and 2′,12 β - O -diacetylcimiracemonol-3- O - β - d -xylopyranoside ( 4 ), together with four known constituents ( 5 – 8 ) were isolated from the roots of Cimicifuga foetida . The new structures were elucidated by extensive spectroscopic analysis. In addition, compounds 7 and 8 showed significant Wnt signaling pathway inhibitory activity, with IC 50 values of 3.33 and 13.34 μM, respectively, using the luciferase reporter gene assay.