Avian sarcoma virus 17 carries the jun oncogene.

作者：Y Maki, Timothy J. Bos, Charles E. L. B. Davis, Michael W. Starbuck, Peter K. Vogt · 发表于：Proceedings of the National Academy of Sciences · 年份：1987 · DOI：10.1073/pnas.84.9.2848 · 被引用次数：448 · 研究领域：Virus-based gene therapy research、Molecular Biology Techniques and Applications、RNA and protein synthesis mechanisms

Biologically active molecular clones of avian sarcoma virus 17 (ASV 17) contain a replication-defective proviral genome of 3.5 kilobases (kb). The genome retains partial gag and env sequences, which flank a cell-derived putative oncogene of 0.93 kb, termed jun. The jun gene lacks preserved coding domains of tyrosine-specific protein kinases. It also shows no significant nucleic acid homology with other known oncogenes. The probable transformation-specific protein in ASV 17-transformed cells is a 55-kDa gag-jun fusion product.