What determines glomerular capillary permeability?

作者：William M. Deen · 发表于：Journal of Clinical Investigation · 年份：2004 · DOI：10.1172/jci23577 · 被引用次数：148 · 研究领域：Renal Diseases and Glomerulopathies、Chronic Kidney Disease and Diabetes、Cell Adhesion Molecules Research

There have been exciting recent advances in our understanding of the structural and molecular biology of the glomerular slit diaphragm, as described in a report in this issue of the JCI. These findings, combined with data on the permeability of the basement membrane and evidence that the endothelium may be a more important barrier than often supposed, are allowing a clearer understanding to emerge of how the 3 parts of the glomerular capillary wall jointly determine its functional properties.